Name the disease in which grotesque facial features are seen? Enumerate the cardiac conditions associtaed

• HURLER'S SYNDROME
• Grotesque facial features - prominent supraorbital ridge, depressed nasal bridge, thick lips, corneal clouding, peg shaped teeth
• CARDIAC CONDITIONS ASSOCIATED ARE

• CAD
• AR
• HOCM
• Mitral annulus calcification (MR)

Differential Diagnosis - Hypertelorism?

 Hypertelorism -Wide set eyes ie  when distance between two eyes more than the size of one eye

• Hurler's Syndrome
• Klippel- Feil Syndrome
• LEOPARD
• Noonan's Syndrome
• Turner's Syndrome
• William's Syndrome

Differential Diagnosis - Micrognathia (llar to Hypognathia)

• Pierre Robin Syndrome
• Cri Du Chat Syndrome
• Fetal Alcohol Syndrome
• Rubenstein Tayabi Syndrome
• Trisomy 13-18
• Treacher Collins Syndrome
• Pyknodystosis

Differential Diagnosis - Hypognathia

• Pierre Robin Syndrome
• Cri-du chat Syndrome
• Fetal Alcohol Syndrome
• Rubenstein Taybi Syndrome
• Trisomy 13,18
• Treacher Collins Syndrome
• Pyknodystosis